Global research trends on Areca catechu L. (Areca nut): A bibliometric analysis from 1970 to 2025

Authors

  • Ave Olivia Rahman Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret; Department of Pharmacology, Faculty of Medicine and Health Sciences, Universitas Jambi
  • Didik Gunawan Tamtomo Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret
  • Adi Prayitno Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret
  • Dicky Moch. Rizal Department of Physiology and Andrology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada
  • Vitri Widyaningsih Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret
  • Risya Cilmiaty A.R Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret
  • Paramasari Dirgahayu Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

DOI:

https://doi.org/10.22437/proca.v1i2.50526

Keywords:

bibliometrics; global research; research trend; scientometrics; thematic map

Abstract

Background: Areca catechu L. (A. catechu), known as areca or betel nut palm, is a tropical tree widely cultivated across South and Southeast Asia, the Pacific Islands, and parts of East Africa. Over the past five decades, A. catechu has garnered substantial scientific attention. Previous bibliometric studies have primarily focused on areca nut as a risk factor in relation to oral health conditions. Methods: A bibliometric analysis of 2,869 publications from 1970 to 2025 was conducted using the Bibliometrix R package (biblioshiny 5.0) to evaluate research trends and collaboration networks. Results: The average yearly growth rate of publications was 7.24%, with India leading the way in terms of publications. The most active author, affiliation, and source are Yang SF, Kaohsiung Medical University, Journal of Oral Pathology & Medicine, respectively. The main topic in the medical field was oral lesions and the risk factors associated with betel nut chewing, including arecoline and oral fibrosis. Emerging topics included antibacterial, antioxidant, and composite material engineering, as well as adsorbents and natural fibers, which are also gaining attention in non-medical fields. Conclusion: Countries with the highest A. catechu plantation production are the most prolific in journal publications. The utilization of areca nut plantation products can be directed towards research into their potential as a natural fiber, hybrid composite, and their polyphenolic compounds as antibacterial and antioxidant agents.

Downloads

Download data is not yet available.

Author Biographies

Ave Olivia Rahman, Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret; Department of Pharmacology, Faculty of Medicine and Health Sciences, Universitas Jambi

Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret; Department of Pharmacology, Faculty of Medicine and Health Sciences, Universitas Jambi

Didik Gunawan Tamtomo, Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

Adi Prayitno, Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

Dicky Moch. Rizal, Department of Physiology and Andrology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada

Department of Physiology and Andrology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada

Vitri Widyaningsih, Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

Risya Cilmiaty A.R, Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

Paramasari Dirgahayu, Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

Doctoral Program of Medicine Sciences, Faculty of Medicine, Universitas Sebelas Maret

References

[1] Singh A, Dikshit R, Chaturvedi P. Betel Nut Use: The South Asian Story. Subst Use Misuse. 2020;55(9):1545–51.

[2] Jannah M, Machfud, Sugiarto. Potential added value of areca nut products in Aceh. J Teknol Ind Pertan. 2021;31(2):190–7.

[3] Peng W, Liu YJ, Wu N, Sun T, He XY, Gao YX, et al. Areca catechu L. (Arecaceae): A review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. J Ethnopharmacol. 2015;164:340–56.

[4] Sun H, Yu W, Li H, Hu X, Wang X. Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs. Nutrients. 2024;16(5):695–718.

[5] Vashney M, Parmar A, Mishra AK. The past, present and future of literature pertaining to betel (areca) nut: a citation analysis. Subst Use Misuse [Internet]. 2020;55(9):1403–12. Available from: https://doi.org/10.1080/10826084.2019.1660677

[6] Sotoudeh-Anvari A. A state-of-the-art review on D number (2012-2022): A scientometric analysis. Eng Appl Artif Intell [Internet]. 2024;127(PA):107309. Available from: https://doi.org/10.1016/j.engappai.2023.107309

[7] Nowakowska M. A comprehensive approach to preprocessing data for bibliometric analysis [Internet]. Vol. 130, Scientometrics. Springer International Publishing; 2025. 5191–5225 p. Available from: https://doi.org/10.1007/s11192-025-05415-x

[8] Lim WM, Kumar S, Donthu N. How to combine and clean bibliometric data and use bibliometric tools synergistically: Guidelines using metaverse research. J Bus Res. 2024;182(May):114760. Available from: https://doi.org/10.1016/j.jbusres.2024.114760

[9] Wang G, Yu Z, Ji T, Shi L, Liu W. A scientometric study of betel quid chewing and oral cancer and precancerous lesions with distinct regional characteristic. J Dent Sci. 2023;18(3):1378–83. Available from: https://doi.org/10.1016/j.jds.2023.03.007

[10] Oyewola DO, Dada EG. Exploring machine learning: a scientometrics approach using bibliometrix and VOSviewer. SN Appl Sci [Internet]. 2022;4(5). Available from: https://doi.org/10.1007/s42452-022-05027-7

[11] Maulidiya D, Nugroho B, Santoso HB, Hasibuan ZA. Thematic evolution of smart learning environments, insights and directions from a 20-year research milestones: A bibliometric analysis. Heliyon [Internet]. 2024;10(5):e26191. Available from: https://doi.org/10.1016/j.heliyon.2024.e26191

[12] Ragazou K, Passas I, Garefalakis A, Dimou I. Investigating the Research Trends on Strategic Ambidexterity, Agility, and Open Innovation in SMEs: Perceptions from Bibliometric Analysis. J Open Innov Technol Mark Complex. 2022;8(118):1–18.

[13] Iman B, Yuadi I, Sukoco BM. Mapping Research Trends With Factorial Analysis in Organizational Politics. 2023;(December):1–16.

[14] Jordaan H. Exploring Biblioshiny for Historical Assessment of Global Research on Sustainable Use of Water in Agriculture. Sustainability. 2022;14(10651):1–34.

[15] Guo S, Cui L, Xu J, Liu M, Wang W, Xia A, et al. A global synthesis of plant-plant interaction investigations: current knowledge and future directions. Plant Soil. 2025;

[16] Ohsugi M, Fan WZ, Hase K, Xiong Q, Tezuka Y, Komatsu K, et al. Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. J Ethnopharmacol. 1999;67(1):111–9.

[17] Lee SE, Hwang HJ, Ha JS, Jeong HS, Kim JH. Screening of medicinal plant extracts for antioxidant activity. LIFE Sci. 2003;73(2):167–79.

[18] Inokuchi J ichi, Okabe H, Yamauchi T, Nagamatsu A, Nonaka G ichiro, Nishioka I. Antihypertensive substance in seeds of Areca catechu L. Vol. 38, Life Sciences. 1986. p. 1375–82.

[19] Hada S, Kakiuchi N, Hattori M, Namba T. Dental-caries prevention by traditional medicines .11. Identification of antibacterial principles against streptococcus-mutans and inhibitory principles against glucosyltransferase from the seed of areca-catechu l. Phyther Res. 1989;3(4):140-144 WE-Science Citation Index Expanded (SCI.

[20] Abbas G, Kashif M, Mudassar, Khan TA, Bhatti HA, Haque S, et al. Cytotoxic, embryotoxic, insecticidal and anti-microbial activities of standardized Areca catechu nut. Pak J Pharm Sci. 2018;31(2):385-392 WE-Science Citation Index Expanded (SCI.

[21] Panutat P, Vatanyoopaisarn S. Antibacterial activity of Thai herb and spice extracts against the potent foodborne bacteria. Franz C, Mathe A, editors. WOCMAP III: Targeted Screening of MAPs, Economics and Law. King Mongkuts Inst Technol, Fac Sci Appl, Dept Agroind Technol, Bangkok, Thailand; 2005. p. 191–6.

[22] Alen Y, Nakajima S, Nitoda T, Baba N, Kanzaki H, Kawazu K. Antinematodal activity of some tropical rainforest plants against the pinewood nematode, Bursaphelenchus xylophilus. Zeitschrift Fur Naturforsch C-A J Biosci. 2000;55(3–4):295-299 WE-Science Citation Index Expanded (SCI.

[23] Selvan RS, Selvakumaran M, Rao AR. Influence of arecoline on immune-system .2. Suppression of thymus-dependent immune-responses and parameter of nonspecific resistance after short-term exposure. Immunopharmacol Immunotoxicol. 1991;13(3):281–309.

[24] Dar A, Khatoon S, Rahman G, AttaUrRahman. Anti-depressant activities of Areca catechu fruit extract. Phytomedicine. 1997;4(1):41–5.

[25] Dar A, Khatoon S. Behavioral and biochemical studies of dichloromethane fraction from the Areca catechu nut. Pharmacol Biochem Behav. 2000;65(1):1–6.

[26] Abbas G, Naqvi S, Erum S, Ahmed S, Atta-ur-Rahman, Dar A. Potential Antidepressant Activity of Areca catechu Nut via Elevation of Serotonin and Noradrenaline in the Hippocampus of Rats. Phyther Res. 2013;27(1):39–45.

[27] Nadig APR, Suman, Sahyadri M, Mehdi S, Krishna KL. Aqueous extract of Piper betle L. leaf and Areca catechu L. nut protects against pentylenetetrazole-induced seizures and positively modulates cognitive function in adult Zebrafish. Adv Tradit Med. 2023;23(4):1137–52.

[28] Goto H, Tanaka N, Tanigawa K, Shimada Y, Itoh T, Terasawa K. Endothelium-dependent vasodilator effect of extract prepared from the seeds of Areca catechu on isolated rat aorta. Phyther Res. 1997;11(6):457–9.

[29] Ghelardini C, Galeotti N, Lelli C, Bartolini A. M1 receptor activation is a requirement for arecoline analgesia. FARMACO. 2001;56(Workshop of the Italian-Society-of-Pharmacognosy (SIPHAR)):383–5.

[30] Khan S, Mehmood MH, Ali ANA, Ahmed FS, Dar A, Gilani AH. Studies on anti-inflammatory and analgesic activities of betel nut in rodents. J Ethnopharmacol. 2011;135(3):654–61.

[31] Park YB, Jeon SM, Byun SJ, Kim HS, Choi MS. Absorption of intestinal free cholesterol is lowered by supplementation of Areca catechu L. extract in rats. LIFE Sci. 2002;70(16):1849–59.

[32] Gilani AH, Ghayur MN, Saify ZS, Ahmed SP, Choudhary MI, Khalid A. Presence of cholinomimetic and acetylcholinesterase inhibitory constituents in betel nut. LIFE Sci. 2004;75(20):2377–89.

[33] Toukairin T, Uchino K, Mizuno T, Nakashima H, Yamamoto N, Ogawara H. New substances against human-immunodeficiency-virus - sulfated 5’-nucleotidase inhibitory polyphenols. Chem Pharm Bull (Tokyo). 1992;40(3):802-804 WE-Science Citation Index Expanded (SCI.

[34] Uchino K, Matsuo T, Iwamoto M, Tonosaki Y, Fukuchi A. New 5’-nucleotidase inhibitors, npf-86ia, npf-86ib, npf-86iia, and npf-86iib from areca-catechu .1. Isolation and biological properties. Planta Med. 1988;(5):419–22.

[35] Matsuo T, Uchino K, Toukairin T, Iwamoto M, Tonosaki Y, Akiyama T, et al. Phosphatase-inhibitory activity and activation of murine macrophages by new 5’-nucleotidase inhibitors, npf-86ia, npf-86ib, npf-86iia and npf-86iib. Chem Pharm Bull (Tokyo). 1989;37(7):1849-1851 WE-Science Citation Index Expanded (S.

[36] Iwamoto M, Matsuo T, Uchino K, Tonosaki Y, Fukuchi A. New 5’-nucleotidase inhibitors, npf-86ia, npf-86ib, npf-86iia, and npf-86iib from areca-catechu .2. Anti-tumor effects. Planta Med. 1988;(5):422-425 WE-Science Citation Index Expanded (SCI.

[37] Chaachouay N, Zidane L. Plant-Derived Natural Products: A Source for Drug Discovery and Development. Drugs Drug Candidates. 2024;3(1):184–207.

[38] Binafsha Manzoor Syed. Plant extracts for drug development: Is it economical? Liaquat Med Res J. 2025;7(1):1–2.

[39] Wang S, Isa NM, Li L, Shi K. Bibliometric visualization analysis of “World Heritage” topic in web of science database using citespace. Multidiscip Rev. 2024;7(11).

Downloads

Published

30-11-2025

How to Cite

Rahman, A. O., Tamtomo, D. G., Prayitno, A., Rizal, D. M., Widyaningsih, V., A.R, R. C., & Dirgahayu, P. (2025). Global research trends on Areca catechu L. (Areca nut): A bibliometric analysis from 1970 to 2025. Proceedings Academic Universitas Jambi, 1(2), 889–906. https://doi.org/10.22437/proca.v1i2.50526

Issue

Section

RESEARCH DISSEMINATION