Anti-Inflammatory Activity of the Ethanol Extract of Etlingera elatior Stems in Carrageenan-Induced Mice (Mus musculus)

Abstract

Inflammation is the body's physiological response to injury or infection involving various inflammatory mediators. This study aims to evaluate the topical anti-inflammatory activity of the ethanol extract of Kecombrang (etlingera elatior) stems on mice induced with carrageenan solution. The research method used was an experimental design with 30 mice randomly divided into 5 treatment groups. The negative control group received vaseline flavum treatment, while the positive control group received 2.5% hydrocortisone acetate treatment. The other treatment groups received Kecombrang stem ethanol extract treatment at various concentrations, namely 5%, 10% and 15%. After induction with carrageenan solution, the volume of exudate, diameter of air bubbles, and number of leukocyte differentiation in the blood were determined. The results showed that the ethanol extract of Kecombrang stems showed significant anti-inflammatory activity in all treatment groups compared to the negative control, with a significant decrease (p <0.05). Apart from that, the anti-inflammatory effect of Batang Kecombrang extract was also shown to be close to the value of the positive control treatment. In conclusion, Kecombrang stem ethanol extract has potential as an effective topical anti-inflammatory agent, which could be a candidate for further development in the treatment of skin inflammation.